Azitra (AZTR) had the highest return in 2023 by a US stock, returning 3,285,614.3%.

ASSET	YEAR	% RETURN
Azitra (AZTR)	2023	3,285,614.29%
Brera Holdings PLC Class B Ordinary Shares (BREA)	2023	1,311,900%
Lottery (SEGG)	2023	11,791.18%
JIN MEDICAL INTERNATIONAL LTD Ordinary Shares (ZJYL)	2023	3,000.63%
Foremost Lithium Resource & Technology Ltd Common stock (FMST)	2023	2,047.77%
Soleno Therapeutics (SLNO)	2023	1,825.84%
X3 (XTKG)	2023	1,334.1%
Carvana (CVNA)	2023	1,000.62%
Diversified Energy (DEC)	2023	971.42%
Applied Opt (AAOI)	2023	895.88%
Myomo (MYO)	2023	854.29%
American Coastal Insurance (ACIC)	2023	767.82%
Clean Energy Technologies, Inc Common Stock (CETY)	2023	703.43%
Neuropace (NPCE)	2023	647.1%
Cipher Mining (CIFR)	2023	614.53%
Bit Digital (BTBT)	2023	582.26%
Bitfarms (BITF)	2023	567.43%
Eyepoint Pharmaceuticals (EYPT)	2023	550.99%
QXO (QXO)	2023	525.37%
Direct Digital (DRCT)	2023	495.2%
Digi Power X (DGXX)	2023	472.5%
MoonLake Immunotherapeutics (MLTX)	2023	469.72%
Olema Pharmaceuticals (OLMA)	2023	465.73%
IREN (IREN)	2023	445.8%
DeFi Technologies (DEFT)	2023	433.58%