Booking (BKNG) had the highest return between 1999 and 2001 by a large-cap US stock, returning 11,452,500%.

ASSET	YEARS	% RETURN
Booking (BKNG)	1999-2001	11,452,500%
NVIDIA (NVDA)	1999-2001	1,174.56%
Laboratory Corporation of America (LH)	1999-2001	1,076.11%
Suzano Papel e Celulose SA ADR (SUZ)	1999-2001	1,068.62%
Biogen (BIIB)	1999-2001	778.78%
Quest Diagnostics (DGX)	1999-2001	707.99%
Qualcomm (QCOM)	1999-2001	670.45%
Neurocrine Biosciences (NBIX)	1999-2001	633%
Logitech International (LOGI)	1999-2001	501.7%
Check Point Software Technologies (CHKP)	1999-2001	420.3%
CACI International (CACI)	1999-2001	369.77%
Copart (CPRT)	1999-2001	347.06%
Coherent (COHR)	1999-2001	330.75%
NVR (NVR)	1999-2001	327.79%
Enterprise Products Partners (EPD)	1999-2001	303.32%
Regeneron Pharmaceuticals (REGN)	1999-2001	302.29%
Lam Research (LRCX)	1999-2001	284.29%
Bio-Techne (TECH)	1999-2001	248.87%
Gildan Activewear (GIL)	1999-2001	237.37%
Infosys Ltd ADR (INFY)	1999-2001	236.22%
Arthur J Gallagher (AJG)	1999-2001	235.99%
Ryanair Holdings PLC ADR (RYAAY)	1999-2001	235.16%
Celestica (CLS)	1999-2001	225.56%
UnitedHealth (UNH)	1999-2001	224.06%
Brown & Brown (BRO)	1999-2001	222.25%

Large-cap stocks are treated as having a market cap of $10B+.