Helport AI Limited Ordinary Shares (HPAI) had the highest return between 2015 and 2022 by a US stock, returning 10,109,900%.

ASSET	YEARS	% RETURN
Helport AI Limited Ordinary Shares (HPAI)	2015-2022	10,109,900%
BioNexus Gene Lab Corp Common stock (BGLC)	2015-2022	2,780,387.8%
KULR Technology (KULR)	2015-2022	2,399,900%
Next Technology (NXTT)	2015-2022	1,162,346.87%
MDxHealth SA ADR (MDXH)	2015-2022	1,101,566.67%
Applied Digital (APLD)	2015-2022	613,233.33%
Connexa Sports Technologies (YYAI)	2015-2022	467,900%
Heart Test Laboratories Inc Common Stock (HSCS)	2015-2022	246,958.82%
AquaBounty Technologies (AQB)	2015-2022	212,122.22%
Immatics (IMTX)	2015-2022	174,100%
OrganiGram (OGI)	2015-2022	159,900%
Iqstel (IQST)	2015-2022	146,895.96%
Integra Resources (ITRG)	2015-2022	126,500%
GT Biopharma (GTBP)	2015-2022	75,842.86%
Blackboxstocks (BLBX)	2015-2022	70,488.24%
Eastside Distilling (BLNE)	2015-2022	68,565.67%
SurgePays (SURG)	2015-2022	65,500%
INVO Fertility (IVF)	2015-2022	29,253.85%
Guardforce AI (GFAI)	2015-2022	24,323.08%
FingerMotion (FNGR)	2015-2022	22,380%
Celsius (CELH)	2015-2022	20,703.84%
LM Funding America (LMFA)	2015-2022	11,051.52%
Avalon GloboCare (ALBT)	2015-2022	11,042.86%
Aura Minerals Inc Common Shares (AUGO)	2015-2022	9,830.32%
Zynex (ZYXI)	2015-2022	9,647.72%