InterContinental Hotels Group PLC ADR (IHG) had the highest return between 1999 and 2010 by a US stock, returning 14,004,900%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	1999-2010	14,004,900%
Northern Oil & Gas (NOG)	1999-2010	8,922,465.38%
QVC (QVCGA)	1999-2010	8,177,603.7%
Know Labs (KNW)	1999-2010	4,885,152.16%
Houston American Energy (HUSA)	1999-2010	4,701,043.45%
Hirequest (HQI)	1999-2010	2,146,250%
National Grid PLC ADR (NGG)	1999-2010	1,128,370.59%
India Globalization Capital (IGC)	1999-2010	966,566.67%
Natwest (NWG)	1999-2010	774,270%
Perspective Therapeutics (CATX)	1999-2010	376,566.67%
Aris Mining (ARMN)	1999-2010	326,680.13%
Gladstone Capital (GLAD)	1999-2010	292,020%
Ferguson (FERG)	1999-2010	212,023.96%
Ring Energy (REI)	1999-2010	133,233.33%
First Majestic Silver (AG)	1999-2010	63,584%
Ocean Power Technologies (OPTT)	1999-2010	63,455.56%
Gyre Therapeutics (GYRE)	1999-2010	56,089.27%
Pioneer Power Solutions (PPSI)	1999-2010	29,429.23%
Companhia Siderurgica Nacional ADR (SID)	1999-2010	24,410.95%
Future Fintech (FTFT)	1999-2010	23,150%
Flexible Solutions International (FSI)	1999-2010	20,896.08%
NanoViricides (NNVC)	1999-2010	20,480%
Weatherford International (WFRD)	1999-2010	15,400%
ImmunoPrecise Antibodies (HYFT)	1999-2010	11,900%
BP Prudhoe Bay Royalty Trust (BPT)	1999-2010	11,880.26%