NVIDIA (NVDA) has had the highest return between 2018 and 2025 by a mega-cap US stock, returning 4,012.2%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	2018-2025	4,012.18%
Advanced Micro Devices (AMD)	2018-2025	2,241.46%
Tesla (TSLA)	2018-2025	2,040.53%
Palantir Technologies Inc Class A Common Stock (PLTR)	2018-2025	1,836.1%
Broadcom (AVGO)	2018-2025	1,615.7%
Eli Lilly and (LLY)	2018-2025	1,187.41%
Lam Research (LRCX)	2018-2025	905.25%
Applovin (APP)	2018-2025	830.46%
Taiwan Semiconductor Manufacturing (TSM)	2018-2025	780.56%
Apple (AAPL)	2018-2025	576.11%
ASML Holding NV ADR (ASML)	2018-2025	545.44%
Microsoft (MSFT)	2018-2025	538.3%
Micron Technology (MU)	2018-2025	524.71%
Netflix (NFLX)	2018-2025	471.17%
Oracle (ORCL)	2018-2025	470.87%
Alphabet Inc Class A (GOOGL)	2018-2025	454.79%
Costco Wholesale (COST)	2018-2025	445.78%
Caterpillar (CAT)	2018-2025	329.58%
Amazon (AMZN)	2018-2025	323.89%
American Express (AXP)	2018-2025	311.14%
Morgan Stanley (MS)	2018-2025	297.58%
GE Aerospace (GE)	2018-2025	292.59%
Mastercard (MA)	2018-2025	280.39%
Goldman Sachs (GS)	2018-2025	267.22%
JPMorgan Chase (JPM)	2018-2025	266.46%

Mega-cap stocks are treated as having a market cap of $200B+.