Regencell Bioscience (RGC) has had the highest return this year by a US stock, returning 6,045.7%.

ASSET	YEAR	% RETURN
Regencell Bioscience (RGC)	2025	6,045.67%
Kindly MD, Inc Warrants (KDLYW)	2025	2,706.25%
Janover Inc Common Stock (JNVR)	2025	1,838.64%
DeFi Development (DFDV)	2025	1,838.64%
Diginex Limited Ordinary Shares (DGNX)	2025	1,707.51%
Mobile Global Esports (MGAM)	2025	1,400%
Asset Entities Inc Class B Common Stock (ASST)	2025	1,094%
HCM II Acquisition (HONDW)	2025	1,012.07%
Splash Beverage Group, Inc WT (SBEV.WT)	2025	960%
Oncology Institute (TOI)	2025	766.01%
Kindly MD, Inc Common Stock (KDLY)	2025	734.68%
Oncology Institute (TOIIW)	2025	721.43%
Aimfinity Investment Corp I Warrant (AIMAW)	2025	542.86%
Global Interactive Technologies (GITS)	2025	522.41%
Webull Corporation Warrants (BULLW)	2025	513.21%
Dominari (DOMH)	2025	507.41%
Oriental Culture Holding (OCG)	2025	484.03%
Marblegate Acquisition Corp Warrant (GATEW)	2025	466.67%
TMC the metals company Inc Warrants (TMCWW)	2025	456.6%
Arena (AREN)	2025	447.1%
Cardio Diagnostics (CDIO)	2025	439.8%
Abits (ABTS)	2025	414.11%
Cohen Circle Acquisition Corp I Warrant (CCIRW)	2025	401.56%
DatChat Inc Series A Warrant (DATSW)	2025	400%
Regulus Therapeutics (RGLS)	2025	390%