Weatherford International (WFRD) had the highest return between 2019 and 2022 by a US stock with a market cap of $1B+, returning 9,477.9%.

ASSET	YEARS	% RETURN
Weatherford International (WFRD)	2019-2022	9,477.91%
Enphase Energy (ENPH)	2019-2022	5,622.68%
Celsius (CELH)	2019-2022	2,969.03%
Applied Digital (APLD)	2019-2022	2,662.76%
Axsome Therapeutics (AXSM)	2019-2022	2,644.84%
Centrus Energy (LEU)	2019-2022	1,880.49%
Celldex Therapeutics (CLDX)	2019-2022	1,385.67%
Moderna (MRNA)	2019-2022	1,103.08%
Plug Power (PLUG)	2019-2022	897.58%
Fubotv (FUBO)	2019-2022	883.05%
Catalyst Pharmaceuticals (CPRX)	2019-2022	878.95%
Lattice Semiconductor (LSCC)	2019-2022	845.77%
BioNTech SE (BNTX)	2019-2022	810.42%
Daqo New Energy Corp ADR (DQ)	2019-2022	738.98%
SolarEdge Technologies (SEDG)	2019-2022	723.22%
Sitime (SITM)	2019-2022	681.69%
Calumet Specialty Products Partners (CLMT)	2019-2022	670.78%
Impinj (PI)	2019-2022	666.18%
Avis Budget (CAR)	2019-2022	642.1%
Cytokinetics (CYTK)	2019-2022	636.66%
Atlanticus (ATLC)	2019-2022	631.84%
Freedom (FRHC)	2019-2022	623.23%
Calix (CALX)	2019-2022	612.81%
Chord Energy (CHRD)	2019-2022	561.33%
ELF Beauty (ELF)	2019-2022	548.3%