Integra Resources (ITRG) has had the highest return this decade by a US stock, returning 609,900%.

ASSET	DECADE	% RETURN
Integra Resources (ITRG)	2020s	609,900%
Everbright Digital Holding Limited Ordinary Shares (EDHL)	2020s	360,900%
MDxHealth SA ADR (MDXH)	2020s	331,718.18%
Synergy CHC Corp Common Stock (SNYR)	2020s	288,233.33%
DevvStream Corp Common Stock (DEVS)	2020s	89,000%
Applied Digital (APLD)	2020s	88,464.81%
BioNexus Gene Lab Corp Common stock (BGLC)	2020s	49,046.34%
COSCIENS Biopharma (CSCI)	2020s	34,645.76%
MKDWELL Tech Inc Ordinary Share (MKDW)	2020s	19,096.43%
Castellum (CTM)	2020s	15,718.18%
Mingteng International Corporation Inc Ordinary Shares (MTEN)	2020s	10,071.43%
Heart Test Laboratories Inc Common Stock (HSCS)	2020s	9,194.12%
Regencell Bioscience (RGC)	2020s	8,676.12%
Foremost Lithium Resource & Technology Ltd Common stock (FMST)	2020s	7,301.81%
Innodata (INOD)	2020s	4,163.16%
VS Media Holdings Limited Class A Ordinary Shares (VSME)	2020s	4,045.66%
Centrus Energy (LEU)	2020s	3,915.12%
QMMM Holdings Limited Ordinary Shares (QMMM)	2020s	3,880%
Celestica (CLS)	2020s	3,741.28%
TechCreate (TCGL)	2020s	3,740.89%
Azitra (AZTR)	2020s	3,487.5%
IsoEnergy (ISOU)	2020s	3,346.1%
Cybin (CYBN)	2020s	3,132.14%
NVIDIA (NVDA)	2020s	3,098.14%
DeFi Technologies (DEFT)	2020s	3,093.28%