Madrigal Pharmaceuticals (MDGL) had the lowest return between 2015 and 2016 by a large-cap US stock, returning -83.9%.

ASSET	YEARS	% RETURN
Madrigal Pharmaceuticals (MDGL)	2015-2016	-83.94%
Arrowhead Pharmaceuticals (ARWR)	2015-2016	-79.9%
Leonardo DRS, Inc Common Stock (DRS)	2015-2016	-76.8%
Tenet Healthcare (THC)	2015-2016	-70.9%
Alnylam Pharmaceuticals (ALNY)	2015-2016	-61.78%
QXO (QXO)	2015-2016	-55.36%
Natwest (NWG)	2015-2016	-54.03%
NRG Energy (NRG)	2015-2016	-52.26%
Allegheny Technologies (ATI)	2015-2016	-52.25%
Ralph Lauren Corp Class A (RL)	2015-2016	-49.56%
MPLX (MPLX)	2015-2016	-49.11%
Telefonaktiebolaget LM Ericsson B ADR (ERIC)	2015-2016	-47.63%
Natera (NTRA)	2015-2016	-47.01%
Kinder Morgan (KMI)	2015-2016	-46.86%
Chipotle Mexican Grill (CMG)	2015-2016	-45%
TIM Participacoes (TIMB)	2015-2016	-44.69%
Globalstar, Inc Common Stock (GSAT)	2015-2016	-43.57%
Ecopetrol SA ADR (EC)	2015-2016	-42.43%
Freeport-McMoran Copper & Gold (FCX)	2015-2016	-41.8%
Cheniere Energy (LNG)	2015-2016	-40.65%
Antero Resources (AR)	2015-2016	-40.36%
Deckers Outdoor (DECK)	2015-2016	-39.61%
Deutsche Bank (DB)	2015-2016	-39.3%
Wynn Resorts (WYNN)	2015-2016	-38.88%
CF Industries (CF)	2015-2016	-38.6%

Large-cap stocks are treated as having a market cap of $10B+.