Madrigal Pharmaceuticals (MDGL) had the lowest return between 2015 and 2016 by a large-cap US stock, returning -83.9%.

ASSET	YEARS	% RETURN
Madrigal Pharmaceuticals (MDGL)	2015-2016	-83.94%
Leonardo DRS, Inc Common Stock (DRS)	2015-2016	-76.8%
Tenet Healthcare (THC)	2015-2016	-70.9%
Alnylam Pharmaceuticals (ALNY)	2015-2016	-61.78%
QXO (QXO)	2015-2016	-55.36%
Natwest (NWG)	2015-2016	-54.03%
NRG Energy (NRG)	2015-2016	-52.26%
Allegheny Technologies (ATI)	2015-2016	-52.25%
EXACT Sciences (EXAS)	2015-2016	-51.59%
Ralph Lauren Corp Class A (RL)	2015-2016	-49.56%
MPLX (MPLX)	2015-2016	-49.11%
Embraer (EMBJ)	2015-2016	-47.91%
Telefonaktiebolaget LM Ericsson B ADR (ERIC)	2015-2016	-47.63%
Energy of Minas Gerais Co DRC (CIG.C)	2015-2016	-47.52%
Natera (NTRA)	2015-2016	-47.01%
Kinder Morgan (KMI)	2015-2016	-46.86%
Chipotle Mexican Grill (CMG)	2015-2016	-45%
Avis Budget (CAR)	2015-2016	-44.75%
TIM Participacoes (TIMB)	2015-2016	-44.69%
Ecopetrol SA ADR (EC)	2015-2016	-42.42%
Freeport-McMoran Copper & Gold (FCX)	2015-2016	-41.8%
Cheniere Energy (LNG)	2015-2016	-40.65%
Antero Resources (AR)	2015-2016	-40.36%
Deckers Outdoor (DECK)	2015-2016	-39.61%
Deutsche Bank (DB)	2015-2016	-39.3%

Large-cap stocks are treated as having a market cap of $10B+.