Applied Digital (APLD) had the lowest return in April 2022 by a mid-cap US stock, returning -78.5%.

ASSET	MONTH	% RETURN
Applied Digital (APLD)	April 2022	-78.46%
Protagonist Therapeutics (PTGX)	April 2022	-61.87%
Terawulf (WULF)	April 2022	-55.15%
Dianthus Therapeutics (DNTH)	April 2022	-51.03%
Riot Blockchain (RIOT)	April 2022	-50.78%
CleanSpark (CLSK)	April 2022	-47.53%
Terns Pharmaceuticals (TERN)	April 2022	-46.67%
Scholar Rock (SRRK)	April 2022	-45.95%
Rhythm Pharmaceuticals (RYTM)	April 2022	-45.52%
Kingsoft Cloud Holdings (KC)	April 2022	-45.23%
Dave (DAVE)	April 2022	-44.14%
BioCryst Pharmaceuticals (BCRX)	April 2022	-42.8%
Twist Bioscience (TWST)	April 2022	-41.74%
Hycroft Mining (HYMC)	April 2022	-41%
TMC the metals (TMC)	April 2022	-39.61%
Spyre Therapeutics (SYRE)	April 2022	-38.98%
10X Genomics (TXG)	April 2022	-37.42%
Century Aluminum (CENX)	April 2022	-36.82%
Hut 8 Corp Common Stock (HUT)	April 2022	-35.74%
Immunitybio (IBRX)	April 2022	-35.64%
Beam Therapeutics (BEAM)	April 2022	-35.36%
Sunrun (RUN)	April 2022	-35.13%
MP Materials (MP)	April 2022	-34.54%
Galaxy Digital (GLXY)	April 2022	-34.32%
GameStop (GME)	April 2022	-33.79%

Mid-cap stocks are treated as having a market cap between $2B and $10B.