SS Innovations International Inc Common Stock (SSII) had the lowest return in 2021 by a small-cap US stock, returning -99.8%.

ASSET	YEAR	% RETURN
SS Innovations International Inc Common Stock (SSII)	2021	-99.81%
Gaotu Techedu Inc DRC (GOTU)	2021	-96.23%
Tian Ruixiang (TIRX)	2021	-89.85%
Enliven Therapeutics (ELVN)	2021	-89.8%
Yatsen (YSG)	2021	-87.35%
Waterdrop Inc ADR (WDH)	2021	-86.54%
Frequency Therapeutics (KRRO)	2021	-85.75%
Gyre Therapeutics (GYRE)	2021	-85.54%
Smart Share Global Ltd ADR (EM)	2021	-85.4%
ARS Pharmaceuticals (SPRY)	2021	-85.2%
D-MARKET Electronic Services & Trading ADR (HEPS)	2021	-85.02%
Katapult Holdings Equity Warrants Exp 09 June 2026 (KPLTW)	2021	-83.62%
Ardelyx (ARDX)	2021	-83.1%
Talkspace (TALK)	2021	-81.64%
Esperion Therapeutics (ESPR)	2021	-80.84%
Olema Pharmaceuticals (OLMA)	2021	-80.69%
Root (ROOT)	2021	-79.69%
InnovAge (INNV)	2021	-79.17%
Abeona Therapeutics (ABEO)	2021	-78.54%
Clover Health Investments (CLOV)	2021	-78.34%
Viant Technology (DSP)	2021	-77.94%
Solid Biosciences LLC (SLDB)	2021	-76.94%
Tuya Inc ADR (TUYA)	2021	-76.85%
Bit Digital (BTBT)	2021	-76.34%
Americas Silver (USAS)	2021	-76.29%

Small-cap stocks are treated as having a market cap between $300M and $2B.