MicroStrategy (MSTR) had the lowest return in April 2000 by a US stock, returning -69.6%.

ASSET	MONTH	% RETURN
MicroStrategy (MSTR)	April 2000	-69.6%
Interlink Electronics (LINK)	April 2000	-66.28%
374Water Inc Common Stock (SCWO)	April 2000	-62.96%
Lifevantage (LFVN)	April 2000	-62.5%
Stabilis Solutions (SLNG)	April 2000	-61.24%
Portage Biotech (PRTG)	April 2000	-60%
BlackBerry (BB)	April 2000	-59.14%
PTC (PTC)	April 2000	-58.96%
eGain (EGAN)	April 2000	-56.25%
Euro Tech (CLWT)	April 2000	-56.12%
Lexicon Pharmaceuticals (LXRX)	April 2000	-55.68%
Crexendo (CXDO)	April 2000	-55.48%
Giga Media (GIGM)	April 2000	-54.72%
American Eagle Outfitters (AEO)	April 2000	-54.67%
NeoGenomics (NEO)	April 2000	-53.33%
Firefly Neuroscience (AIFF)	April 2000	-51.73%
Rand Capital (RAND)	April 2000	-51.61%
Radcom (RDCM)	April 2000	-50.72%
Asure Software (ASUR)	April 2000	-50.37%
MEDIFAST (MED)	April 2000	-50%
TG Therapeutics (TGTX)	April 2000	-50%
8x8 Inc Common Stock (EGHT)	April 2000	-49.58%
Rockwell Medical (RMTI)	April 2000	-48.76%
VirnetX Holding Corp Common Stock (VHC)	April 2000	-48.36%
Merit Medical Systems (MMSI)	April 2000	-47.95%