MDxHealth SA ADR (MDXH) had the lowest return between 2020 and 2022 by a US stock, returning -100%.

ASSET	YEARS	% RETURN
MDxHealth SA ADR (MDXH)	2020-2022	-99.99%
Quhuo (QH)	2020-2022	-99.92%
Jiuzi (JZXN)	2020-2022	-99.75%
Agrify (AGFY)	2020-2022	-99.74%
MetaVia (MTVA)	2020-2022	-99.74%
Entero Therapeutics (ENTO)	2020-2022	-99.72%
Oceanpal (OP)	2020-2022	-99.68%
TOP Ships (TOPS)	2020-2022	-99.67%
Fangdd Network (DUO)	2020-2022	-99.66%
Ensysce Biosciences (ENSC)	2020-2022	-99.64%
Lottery, Inc Warrants (LTRYW)	2020-2022	-99.61%
Gryphon Digital Mining (GRYP)	2020-2022	-99.6%
Nuwellis (NUWE)	2020-2022	-99.59%
Catheter Precision (VTAK)	2020-2022	-99.57%
Greenlane (GNLN)	2020-2022	-99.56%
Enveric Biosciences (ENVB)	2020-2022	-99.54%
Akanda (AKAN)	2020-2022	-99.5%
Tantech (TANH)	2020-2022	-99.49%
Sonnet Biotherapeutics (SONN)	2020-2022	-99.44%
Jianzhi Education Technology Group Company Limited American Depositary Shares (JZ)	2020-2022	-99.41%
E-Home Household Service (EJH)	2020-2022	-99.3%
Aprea Therapeutics (APRE)	2020-2022	-99.28%
Ucommune International (UK)	2020-2022	-99.26%
Vyne Therapeutics (VYNE)	2020-2022	-99.21%
AEye (LIDRW)	2020-2022	-99.19%