Houston American Energy (HUSA) had the highest return between 2001 and 2002 by a US stock, returning 89,885%.

ASSET	YEARS	% RETURN
Houston American Energy (HUSA)	2001-2002	89,885.03%
Interlink Electronics (LINK)	2001-2002	25,831.58%
ImmunoPrecise Antibodies (HYFT)	2001-2002	17,042.86%
MEDIFAST (MED)	2001-2002	3,684.96%
Xcel Brands (XELB)	2001-2002	3,400%
Gladstone Capital (GLAD)	2001-2002	2,983.32%
Arena (AREN)	2001-2002	2,245.69%
Versus Systems Inc. (VS)	2001-2002	1,900%
Ziff Davis (ZD)	2001-2002	1,592.33%
DeFi Technologies (DEFT)	2001-2002	900%
Smith & Wesson Brands (SWBI)	2001-2002	835.2%
Hecla Mining (HL)	2001-2002	799.6%
Tractor Supply (TSCO)	2001-2002	784.81%
Clean Harbors (CLH)	2001-2002	773.57%
Royal Gold (RGLD)	2001-2002	765.89%
Ovintiv (OVV)	2001-2002	765.79%
Caledonia Mining (CMCL)	2001-2002	743.42%
Odyssey Marine Exploration (OMEX)	2001-2002	713.33%
PetMed Express (PETS)	2001-2002	640.02%
Option Care Health (OPCH)	2001-2002	613.85%
USANA Health Sciences (USNA)	2001-2002	588.73%
Sleep Number (SNBR)	2001-2002	553.94%
DRDGOLD Limited ADR (DRD)	2001-2002	548.04%
Acadia Healthcare (ACHC)	2001-2002	530.77%
FTI Consulting (FCN)	2001-2002	502.27%