InterContinental Hotels Group PLC ADR (IHG) had the highest return between 2001 and 2022 by a US stock, returning 55,379,100%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	2001-2022	55,379,100%
Weatherford International (WFRD)	2001-2022	12,489,500%
Amerant Bancorp (AMTB)	2001-2022	8,533,633.33%
Hirequest (HQI)	2001-2022	7,550,700%
DarioHealth (DRIO)	2001-2022	6,114,185.71%
Ferguson (FERG)	2001-2022	4,169,882.76%
BioNexus Gene Lab Corp Common stock (BGLC)	2001-2022	2,780,387.8%
KULR Technology (KULR)	2001-2022	2,399,900%
National Grid PLC ADR (NGG)	2001-2022	2,343,480.95%
Next Technology (NXTT)	2001-2022	1,162,346.87%
Inventrust Properties (IVT)	2001-2022	1,075,625%
Northern Oil & Gas (NOG)	2001-2022	1,036,492.31%
Cemtrex (CETX)	2001-2022	1,031,471.16%
Sequans Communications (SQNS)	2001-2022	999,900%
Sandstorm Gold Ltd N (SAND)	2001-2022	851,700%
MDxHealth SA ADR (MDXH)	2001-2022	734,344.44%
Diversified Energy (DEC)	2001-2022	579,200%
Natwest (NWG)	2001-2022	527,410%
GreenPower Motor (GP)	2001-2022	480,455.56%
180 Life Sciences (ATNF)	2001-2022	252,488.24%
Heart Test Laboratories Inc Common Stock (HSCS)	2001-2022	246,958.82%
AquaBounty Technologies (AQB)	2001-2022	212,122.22%
Immatics (IMTX)	2001-2022	174,100%
OPTIMIZERx (OPRX)	2001-2022	167,900%
Know Labs (KNW)	2001-2022	162,749.87%