Sandisk (SNDK) has had the highest return between 2025 and 2026 by a large-cap US stock, returning 3,794.4%.

ASSET	YEARS	% RETURN
Sandisk (SNDK)	2025-2026	3,794.41%
Micron Technology (MU)	2025-2026	958.68%
Bloom Energy (BE)	2025-2026	889.12%
Lumentum (LITE)	2025-2026	877.32%
Western Digital (WDC)	2025-2026	709.15%
Seagate Technology (STX)	2025-2026	691.74%
Nebius (NBIS)	2025-2026	509.49%
Moderna (MRNA)	2025-2026	473.65%
Guardant Health (GH)	2025-2026	420.29%
Intel (INTC)	2025-2026	353.24%
Revolution Medicines (RVMD)	2025-2026	347.42%
Advanced Micro Devices (AMD)	2025-2026	337.27%
ASE Industrial Holding Co Ltd ADR (ASX)	2025-2026	326.18%
AngloGold Ashanti (AU)	2025-2026	316.63%
Frontline (FRO)	2025-2026	315.43%
Dell Technologies (DELL)	2025-2026	312.03%
Ciena (CIEN)	2025-2026	301.96%
Grupo Cibest (CIB)	2025-2026	296.08%
Millicom International Cellular (TIGO)	2025-2026	282.4%
TTM Technologies (TTMI)	2025-2026	282.19%
HF Sinclair (DINO)	2025-2026	280.54%
Valero Energy (VLO)	2025-2026	267.95%
Lam Research (LRCX)	2025-2026	266.73%
BrightSpring Health Services, Inc Common Stock (BTSG)	2025-2026	262.91%
Tower Semiconductor (TSEM)	2025-2026	253.42%

Large-cap stocks are treated as having a market cap of $10B+.