Sandisk (SNDK) has had the highest return between 2025 and 2026 by a large-cap US stock, returning 4,875.6%.

ASSET	YEARS	% RETURN
Sandisk (SNDK)	2025-2026	4,875.56%
Abivax SA American Depositary Shares (ABVX)	2025-2026	1,888.81%
Bloom Energy (BE)	2025-2026	1,210.75%
Western Digital (WDC)	2025-2026	1,182.12%
Micron Technology (MU)	2025-2026	1,063.27%
Seagate Technology (STX)	2025-2026	917.41%
ViaSat (VSAT)	2025-2026	852.27%
Lumentum (LITE)	2025-2026	768.88%
Nebius (NBIS)	2025-2026	657.27%
Planet Labs PBC (PL)	2025-2026	654.52%
Silicon Motion Technology (SIMO)	2025-2026	507.04%
Intel (INTC)	2025-2026	504.05%
TTM Technologies (TTMI)	2025-2026	497.8%
Vicor (VICR)	2025-2026	485.67%
Guardant Health (GH)	2025-2026	440.22%
Argan (AGX)	2025-2026	429.11%
Enlight Renewable Energy Ltd Ordinary Shares (ENLT)	2025-2026	416.12%
Ciena (CIEN)	2025-2026	409.97%
Hut 8 Corp Common Stock (HUT)	2025-2026	391.85%
Lam Research (LRCX)	2025-2026	386.98%
Arrowhead Pharmaceuticals (ARWR)	2025-2026	356.97%
ASE Industrial Holding Co Ltd ADR (ASX)	2025-2026	352.83%
Advanced Micro Devices (AMD)	2025-2026	351.43%
Millicom International Cellular (TIGO)	2025-2026	347.05%
EchoStar (SATS)	2025-2026	338.63%

Large-cap stocks are treated as having a market cap of $10B+.