QXO (QXO) had the highest return between 2011 and 2013 by a large-cap US stock, returning 2,352,000%.

ASSET	YEARS	% RETURN
QXO (QXO)	2011-2013	2,352,000%
Regeneron Pharmaceuticals (REGN)	2011-2013	741.97%
Cheniere Energy (LNG)	2011-2013	667.25%
Alnylam Pharmaceuticals (ALNY)	2011-2013	548.84%
Tesla (TSLA)	2011-2013	460.44%
Generac (GNRC)	2011-2013	426.06%
Tyler Technologies (TYL)	2011-2013	387.73%
Domino's Pizza Inc Common Stock (DPZ)	2011-2013	373.73%
Mr Cooper (COOP)	2011-2013	347.62%
Seagate Technology (STX)	2011-2013	314.28%
Biogen (BIIB)	2011-2013	313.08%
Gilead Sciences (GILD)	2011-2013	309.93%
Contura Energy (CTRA)	2011-2013	307.73%
Manhattan Associates (MANH)	2011-2013	281.92%
Corpay (CPAY)	2011-2013	274.94%
Mastercard (MA)	2011-2013	272%
Targa Resources (TRGP)	2011-2013	258.83%
Builders FirstSource (BLDR)	2011-2013	256.5%
Charter Communications (CHTR)	2011-2013	249.95%
United Rentals (URI)	2011-2013	236.86%
Axon Enterprise (AXON)	2011-2013	234.32%
Visa Inc Class A (V)	2011-2013	223.84%
Tractor Supply (TSCO)	2011-2013	223.62%
CoStar (CSGP)	2011-2013	217.8%
Constellation Brands Inc Class A (STZ)	2011-2013	217.31%

Large-cap stocks are treated as having a market cap of $10B+.