QXO (QXO) had the highest return between 2011 and 2017 by a large-cap US stock, returning 4,956,500%.

ASSET	YEARS	% RETURN
QXO (QXO)	2011-2017	4,956,500%
NVIDIA (NVDA)	2011-2017	1,245.18%
Domino's Pizza Inc Common Stock (DPZ)	2011-2017	1,243.92%
Texas Pacific Land Trust (TPL)	2011-2017	1,184.96%
Alnylam Pharmaceuticals (ALNY)	2011-2017	1,182.04%
Genmab A-S (GMAB)	2011-2017	1,127.85%
Tesla (TSLA)	2011-2017	1,059.98%
Regeneron Pharmaceuticals (REGN)	2011-2017	1,050.08%
Celsius (CELH)	2011-2017	1,041.55%
Align Technology (ALGN)	2011-2017	1,025.01%
Builders FirstSource (BLDR)	2011-2017	989.5%
Constellation Brands Inc Class A (STZ)	2011-2017	959.55%
NetEase (NTES)	2011-2017	933.19%
Neurocrine Biosciences (NBIX)	2011-2017	905.05%
Broadcom (AVGO)	2011-2017	902.93%
Cheniere Energy (LNG)	2011-2017	858%
Take-Two Interactive Software (TTWO)	2011-2017	791.07%
XPO Logistics (XPO)	2011-2017	764.06%
Charter Communications (CHTR)	2011-2017	759.67%
Tyler Technologies (TYL)	2011-2017	745.51%
Centene (CNC)	2011-2017	689.36%
Netflix (NFLX)	2011-2017	667.84%
United Rentals (URI)	2011-2017	642.92%
Monolithic Power Systems (MPWR)	2011-2017	640.54%
Burlington Stores (BURL)	2011-2017	623.71%

Large-cap stocks are treated as having a market cap of $10B+.