Seagate Technology (STX) had the highest return between 2009 and 2013 by a mega-cap US stock, returning 1,294.9%.

ASSET	YEARS	% RETURN
Seagate Technology (STX)	2009-2013	1,294.88%
Netflix (NFLX)	2009-2013	1,147.24%
Micron Technology (MU)	2009-2013	720.76%
Tesla (TSLA)	2009-2013	691.72%
Amazon (AMZN)	2009-2013	676.61%
Apple (AAPL)	2009-2013	575.63%
Mastercard (MA)	2009-2013	488.15%
American Express (AXP)	2009-2013	437.31%
ASML Holding NV New York Registry Shares (ASML)	2009-2013	410.79%
Visa Inc Class A (V)	2009-2013	336.57%
Home Depot (HD)	2009-2013	310.78%
Amphenol (APH)	2009-2013	278.51%
Alphabet Inc Class A (GOOGL)	2009-2013	263.16%
Alphabet Inc Class C (GOOG)	2009-2013	263.16%
KLA (KLAC)	2009-2013	243.48%
Broadcom (AVGO)	2009-2013	238.33%
Thermo Fisher Scientific (TMO)	2009-2013	230.83%
Texas Instruments (TXN)	2009-2013	216.87%
UnitedHealth (UNH)	2009-2013	198.56%
Royal Bank of Canada (RY)	2009-2013	179.07%
SAP SE ADR (SAP)	2009-2013	166.35%
Taiwan Semiconductor Manufacturing (TSM)	2009-2013	164.55%
Costco Wholesale (COST)	2009-2013	158.5%
Lam Research (LRCX)	2009-2013	153.61%
Philip Morris International (PM)	2009-2013	146.63%

Mega-cap stocks are treated as having a market cap of $200B+.