RadNet (RDNT) had the highest return between 2000 and 2001 by a US stock with a market cap of $2B+, returning 1,523.5%.

ASSET	YEARS	% RETURN
RadNet (RDNT)	2000-2001	1,523.53%
CarMax (KMX)	2000-2001	910.67%
Option Care Health (OPCH)	2000-2001	630.26%
FTI Consulting (FCN)	2000-2001	556.01%
NVIDIA (NVDA)	2000-2001	466.63%
Caesars Entertainment (CZR)	2000-2001	401.96%
Itron (ITRI)	2000-2001	399.79%
Freedom (FRHC)	2000-2001	380%
Meritage (MTH)	2000-2001	377.19%
Quest Diagnostics (DGX)	2000-2001	365.46%
Laboratory Corporation of America (LH)	2000-2001	338.52%
NVR (NVR)	2000-2001	327.23%
CoreSite Realty (COR)	2000-2001	310.19%
Manhattan Associates (MANH)	2000-2001	277.65%
DaVita HealthCare Partners (DVA)	2000-2001	262.22%
Perdoceo Education (PRDO)	2000-2001	260.85%
Ionis Pharmaceuticals (IONS)	2000-2001	251.44%
OSI Systems (OSIS)	2000-2001	250.56%
CACI International (CACI)	2000-2001	249.08%
Penn National Gaming (PENN)	2000-2001	238.27%
Brightstar Lottery (BRSL)	2000-2001	235.21%
Altria (MO)	2000-2001	234.95%
M/I Homes (MHO)	2000-2001	225.15%
Everest (EG)	2000-2001	213.27%
Merit Medical Systems (MMSI)	2000-2001	211.33%