QXO (QXO) had the highest return between 2008 and 2013 by a large-cap US stock, returning 1,045,277.8%.

ASSET	YEARS	% RETURN
QXO (QXO)	2008-2013	1,045,277.78%
Netflix (NFLX)	2008-2013	1,286.29%
Regeneron Pharmaceuticals (REGN)	2008-2013	1,045.88%
Booking (BKNG)	2008-2013	895.65%
Tractor Supply (TSCO)	2008-2013	797.2%
Jazz Pharmaceuticals (JAZZ)	2008-2013	748.26%
Tyler Technologies (TYL)	2008-2013	695.4%
Tesla (TSLA)	2008-2013	691.72%
Generac (GNRC)	2008-2013	561.22%
Dollar Tree (DLTR)	2008-2013	553.01%
Ross Stores (ROST)	2008-2013	528.57%
XPO Logistics (XPO)	2008-2013	497.55%
Domino's Pizza Inc Common Stock (DPZ)	2008-2013	476.93%
Ulta Beauty (ULTA)	2008-2013	474.12%
Transdigm (TDG)	2008-2013	435.03%
Old Dominion Freight Line (ODFL)	2008-2013	425.52%
Incyte (INCY)	2008-2013	404.28%
Biogen (BIIB)	2008-2013	391.25%
LyondellBasell Industries (LYB)	2008-2013	380.22%
TJX Companies (TJX)	2008-2013	379.98%
Corpay (CPAY)	2008-2013	368.68%
Baidu (BIDU)	2008-2013	350.9%
Manhattan Associates (MANH)	2008-2013	347.2%
Westinghouse Air Brake Technologies (WAB)	2008-2013	336.19%
Cognex (CGNX)	2008-2013	326.86%

Large-cap stocks are treated as having a market cap of $10B+.