Aegon NV ADR (AEG) had the highest return between 1988 and 1993 by a large-cap US stock, returning 21,003.2%.

ASSET	YEARS	% RETURN
Aegon NV ADR (AEG)	1988-1993	21,003.17%
Suncor Energy (SU)	1988-1993	11,461.4%
UnitedHealth (UNH)	1988-1993	4,102.51%
Cisco Systems (CSCO)	1988-1993	2,221.67%
Jack Henry & Associates (JKHY)	1988-1993	1,749.09%
Home Depot (HD)	1988-1993	1,348.66%
Electronic Arts (EA)	1988-1993	1,332.86%
PTC (PTC)	1988-1993	1,228.59%
Fastenal (FAST)	1988-1993	1,164.96%
Southwest Airlines (LUV)	1988-1993	1,144.92%
Charles Schwab (SCHW)	1988-1993	1,139.78%
Johnson Controls International (JCI)	1988-1993	1,032.21%
Telefonaktiebolaget LM Ericsson B ADR (ERIC)	1988-1993	1,001.01%
Coca-Cola Consolidated (COKE)	1988-1993	928.92%
Teva Pharma Industries Ltd ADR (TEVA)	1988-1993	921.92%
Cardinal Health (CAH)	1988-1993	879.83%
Amgen (AMGN)	1988-1993	850.38%
Devon Energy (DVN)	1988-1993	771.99%
Jefferies Financial (JEF)	1988-1993	752.7%
Magna International (MGA)	1988-1993	746.04%
Franklin Resources (BEN)	1988-1993	724.78%
Best Buy (BBY)	1988-1993	720.5%
Lowe's Companies (LOW)	1988-1993	705.91%
Leonardo DRS, Inc Common Stock (DRS)	1988-1993	700%
Oracle (ORCL)	1988-1993	693.44%

Large-cap stocks are treated as having a market cap of $10B+.