AngloGold Ashanti (AU) had the highest return between 1998 and 2008 by a large-cap US stock, returning 11,570,550%.

ASSET	YEARS	% RETURN
AngloGold Ashanti (AU)	1998-2008	11,570,550%
InterContinental Hotels Group PLC ADR (IHG)	1998-2008	5,519,600%
National Grid PLC ADR (NGG)	1998-2008	1,018,952.94%
Natwest (NWG)	1998-2008	953,400%
Monster Beverage (MNST)	1998-2008	14,606.32%
Cognizant Technology Solutions Corp Class A (CTSH)	1998-2008	4,234.56%
Clean Harbors (CLH)	1998-2008	3,659.18%
Apple (AAPL)	1998-2008	2,404.59%
Gilead Sciences (GILD)	1998-2008	2,039.26%
NVR (NVR)	1998-2008	1,985.71%
Sterling Construction (STRL)	1998-2008	1,880.97%
Banco Bradesco SA ADR (BBD)	1998-2008	1,695.66%
Laboratory Corporation of America (LH)	1998-2008	1,372.18%
Altria (MO)	1998-2008	1,319.77%
Rogers Communications (RCI)	1998-2008	1,224.26%
Southern Copper (SCCO)	1998-2008	1,195.01%
Quest Diagnostics (DGX)	1998-2008	1,176.62%
Qualcomm (QCOM)	1998-2008	1,141.96%
Royal Gold (RGLD)	1998-2008	1,126.58%
CH Robinson Worldwide (CHRW)	1998-2008	1,021.53%
Chunghwa Telecom (CHT)	1998-2008	996.6%
ResMed (RMD)	1998-2008	961.42%
Elbit Systems (ESLT)	1998-2008	960.21%
BlackRock (BLK)	1998-2008	941.39%
Deckers Outdoor (DECK)	1998-2008	930.47%

Large-cap stocks are treated as having a market cap of $10B+.