AngloGold Ashanti (AU) had the highest return between 1998 and 2003 by a large-cap US stock, returning 18,387,050%.

ASSET	YEARS	% RETURN
AngloGold Ashanti (AU)	1998-2003	18,387,050%
InterContinental Hotels Group PLC ADR (IHG)	1998-2003	5,929,900%
Insmed (INSM)	1998-2003	67,708.22%
Cognizant Technology Solutions Corp Class A (CTSH)	1998-2003	2,638.49%
NVR (NVR)	1998-2003	2,030.29%
eBay (EBAY)	1998-2003	1,349.21%
Axon Enterprise (AXON)	1998-2003	1,076.79%
Tractor Supply (TSCO)	1998-2003	994.67%
Amazon (AMZN)	1998-2003	952.4%
Qualcomm (QCOM)	1998-2003	786.03%
Pool (POOL)	1998-2003	782.38%
Quest Diagnostics (DGX)	1998-2003	766.47%
Best Buy (BBY)	1998-2003	752.94%
Laboratory Corporation of America (LH)	1998-2003	744.54%
Harmony Gold Mining (HMY)	1998-2003	735.23%
Ryanair Holdings PLC ADR (RYAAY)	1998-2003	710.54%
Tapestry (TPR)	1998-2003	654.99%
Neurocrine Biosciences (NBIX)	1998-2003	581.75%
Biogen (BIIB)	1998-2003	540.58%
Genesis Healthcare (GEN)	1998-2003	523.74%
Gilead Sciences (GILD)	1998-2003	509.49%
Chunghwa Telecom (CHT)	1998-2003	501.4%
ResMed (RMD)	1998-2003	488.2%
Copart (CPRT)	1998-2003	477.78%
Logitech International (LOGI)	1998-2003	471.86%

Large-cap stocks are treated as having a market cap of $10B+.