Monster Beverage (MNST) had the highest return between 2004 and 2008 by a large-cap US stock, returning 3,086.1%.

ASSET	YEARS	% RETURN
Monster Beverage (MNST)	2004-2008	3,086.09%
Expedia (EXPE)	2004-2008	1,938.31%
Banco Bradesco SA ADR (BBD)	2004-2008	728.74%
Apple (AAPL)	2004-2008	692.22%
Intuitive Surgical (ISRG)	2004-2008	642.63%
Illumina (ILMN)	2004-2008	613.7%
Clean Harbors (CLH)	2004-2008	613.61%
Elbit Systems (ESLT)	2004-2008	505.7%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2004-2008	488.19%
First Solar (FSLR)	2004-2008	463.1%
Grupo Cibest (CIB)	2004-2008	442.92%
Stifel Financial (SF)	2004-2008	380.14%
Credicorp (BAP)	2004-2008	341.93%
Agnico Eagle Mines (AEM)	2004-2008	330.06%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2004-2008	325.11%
Ambev SA ADR (ABEV)	2004-2008	320.3%
Sterling Construction (STRL)	2004-2008	314.54%
Booking (BKNG)	2004-2008	308.07%
Alnylam Pharmaceuticals (ALNY)	2004-2008	305.41%
Vale SA ADR (VALE)	2004-2008	297.42%
Nucor (NUE)	2004-2008	283.51%
Rogers Communications (RCI)	2004-2008	278.08%
Deckers Outdoor (DECK)	2004-2008	274.99%
America Movil SAB de CV ADR (AMX)	2004-2008	268.24%
Mastercard (MA)	2004-2008	257.63%

Large-cap stocks are treated as having a market cap of $10B+.