Expedia (EXPE) had the highest return between 2005 and 2009 by a large-cap US stock, returning 6,265.6%.

ASSET	YEARS	% RETURN
Expedia (EXPE)	2005-2009	6,265.62%
Booking (BKNG)	2005-2009	820.75%
Banco Bradesco SA ADR (BBD)	2005-2009	772.17%
Monster Beverage (MNST)	2005-2009	721.57%
Intuitive Surgical (ISRG)	2005-2009	658.21%
Suzano Papel e Celulose SA ADR (SUZ)	2005-2009	610.97%
Illumina (ILMN)	2005-2009	551.38%
Apple (AAPL)	2005-2009	550.61%
Mastercard (MA)	2005-2009	542.75%
Trip Group Ltd ADR (TCOM)	2005-2009	536.25%
Baidu (BIDU)	2005-2009	523.08%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2005-2009	513.46%
Southern Copper (SCCO)	2005-2009	512.63%
Credicorp (BAP)	2005-2009	471.71%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2005-2009	470.11%
CF Industries (CF)	2005-2009	468.42%
First Solar (FSLR)	2005-2009	452.65%
Wheaton Precious Metals (WPM)	2005-2009	409.15%
Tenaris SA ADR (TS)	2005-2009	387.9%
Vale SA ADR (VALE)	2005-2009	349.87%
Salesforce (CRM)	2005-2009	349.55%
Netflix (NFLX)	2005-2009	341.39%
Itau Unibanco Banco (ITUB)	2005-2009	333.68%
Stifel Financial (SF)	2005-2009	327.22%
Ambev SA ADR (ABEV)	2005-2009	307.4%

Large-cap stocks are treated as having a market cap of $10B+.