Booking (BKNG) had the highest return between 2006 and 2009 by a large-cap US stock, returning 878.6%.

ASSET	YEARS	% RETURN
Booking (BKNG)	2006-2009	878.57%
Mastercard (MA)	2006-2009	542.75%
Baidu (BIDU)	2006-2009	540.05%
CF Industries (CF)	2006-2009	504.81%
First Solar (FSLR)	2006-2009	452.65%
Trip Group Ltd ADR (TCOM)	2006-2009	397.48%
Ambev SA ADR (ABEV)	2006-2009	374.66%
Illumina (ILMN)	2006-2009	330.6%
Southern Copper (SCCO)	2006-2009	285.97%
Credicorp (BAP)	2006-2009	282.15%
Deckers Outdoor (DECK)	2006-2009	257.03%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2006-2009	244.69%
Halozyme Therapeutics (HALO)	2006-2009	222.53%
Intercontinental Exchange (ICE)	2006-2009	207.67%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2006-2009	201.31%
Vale SA ADR (VALE)	2006-2009	201.27%
POSCO (PKX)	2006-2009	192.15%
Apple (AAPL)	2006-2009	191.14%
Itau Unibanco Banco (ITUB)	2006-2009	190.94%
Elbit Systems (ESLT)	2006-2009	183.72%
Amazon (AMZN)	2006-2009	183.38%
Eldorado Gold (EGO)	2006-2009	182.27%
TechnipFMC (FTI)	2006-2009	180.78%
Align Technology (ALGN)	2006-2009	180.63%
Skyworks Solutions (SWKS)	2006-2009	176.61%

Large-cap stocks are treated as having a market cap of $10B+.