Ferguson (FERG) had the highest return between 2010 and 2012 by a large-cap US stock, returning 24,380.9%.

ASSET	YEARS	% RETURN
Ferguson (FERG)	2010-2012	24,380.86%
Cheniere Energy (LNG)	2010-2012	651.23%
Regeneron Pharmaceuticals (REGN)	2010-2012	605.73%
Domino's Pizza Inc Common Stock (DPZ)	2010-2012	451.66%
Ulta Beauty (ULTA)	2010-2012	416.69%
Lululemon Athletica (LULU)	2010-2012	393.72%
United Rentals (URI)	2010-2012	358.87%
Tractor Supply (TSCO)	2010-2012	242.74%
Westlake Chemical (WLK)	2010-2012	239.56%
XPO Logistics (XPO)	2010-2012	234.16%
Chipotle Mexican Grill (CMG)	2010-2012	231.99%
LyondellBasell Industries (LYB)	2010-2012	231.8%
Las Vegas Sands (LVS)	2010-2012	221.6%
Lennar (LEN.B)	2010-2012	217.21%
Transdigm (TDG)	2010-2012	210.18%
Lennar (LEN)	2010-2012	209.36%
Booking (BKNG)	2010-2012	179.05%
Ecopetrol SA ADR (EC)	2010-2012	176.35%
Monster Beverage (MNST)	2010-2012	173.36%
Biogen (BIIB)	2010-2012	171.21%
Neurocrine Biosciences (NBIX)	2010-2012	170.04%
Discover Financial Services (DFS)	2010-2012	166.77%
U-Haul (UHAL)	2010-2012	164.99%
Expedia (EXPE)	2010-2012	164.72%
Novo Nordisk A-S (NVO)	2010-2012	163.19%

Large-cap stocks are treated as having a market cap of $10B+.