NVIDIA (NVDA) had the highest return between 2021 and 2024 by a US stock with a market cap of $100B+, returning 927.3%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	2021-2024	927.31%
Arista Networks (ANET)	2021-2024	508.23%
Constellation Energy (CEG)	2021-2024	505.44%
Broadcom (AVGO)	2021-2024	481.3%
Eli Lilly and (LLY)	2021-2024	377.67%
Applovin (APP)	2021-2024	362.61%
KKR (KKR)	2021-2024	279.31%
Dell Technologies (DELL)	2021-2024	229.79%
Palantir Technologies Inc Class A Common Stock (PLTR)	2021-2024	216.31%
GE Aerospace (GE)	2021-2024	212.57%
Palo Alto Networks (PANW)	2021-2024	207.21%
Exxon Mobil (XOM)	2021-2024	206.36%
Blackstone (BX)	2021-2024	205.8%
Mitsubishi UFJ Financial Group Inc ADR (MUFG)	2021-2024	205.54%
Eaton (ETN)	2021-2024	196.38%
Interactive Brokers (IBKR)	2021-2024	193.92%
GE Vernova LLC (GEV)	2021-2024	186.24%
ConocoPhillips (COP)	2021-2024	181.66%
Oracle (ORCL)	2021-2024	173.46%
Sumitomo Mitsui Financial (SMFG)	2021-2024	173.01%
Progressive (PGR)	2021-2024	165.55%
American Express (AXP)	2021-2024	157.49%
Novo Nordisk A-S (NVO)	2021-2024	156.16%
Costco Wholesale (COST)	2021-2024	155.24%
Wells Fargo (WFC)	2021-2024	154.41%