QXO (QXO) had the highest return between 2010 and 2013 by a US stock with a market cap of $1B+, returning 2,352,000%.

ASSET	YEARS	% RETURN
QXO (QXO)	2010-2013	2,352,000%
Sandstorm Gold Ltd N (SAND)	2010-2013	456,211.11%
Ferguson (FERG)	2010-2013	454,040.45%
Par Pacific (PARR)	2010-2013	3,616.67%
Aris Mining (ARMN)	2010-2013	2,325.31%
ACADIA Pharmaceuticals (ACAD)	2010-2013	1,793.18%
Cheniere Energy (LNG)	2010-2013	1,624.8%
Jazz Pharmaceuticals (JAZZ)	2010-2013	1,470.22%
Nexstar Broadcasting (NXST)	2010-2013	1,301.91%
Vipshop (VIPS)	2010-2013	1,294.64%
Virtus Investment Partners (VRTS)	2010-2013	1,136.78%
Patrick Industries (PATK)	2010-2013	1,076.07%
Regeneron Pharmaceuticals (REGN)	2010-2013	1,035.48%
Melco Resorts & Entertainment (MLCO)	2010-2013	1,030.24%
Acadia Healthcare (ACHC)	2010-2013	956.47%
Astronics (ATRO)	2010-2013	925.68%
BioLife Solutions (BLFS)	2010-2013	900%
Red Cat (RCAT)	2010-2013	850%
Domino's Pizza Inc Common Stock (DPZ)	2010-2013	794.14%
Lithia Motors (LAD)	2010-2013	785.4%
Bausch Health Companies (BHC)	2010-2013	785.27%
DXP Enterprises (DXPE)	2010-2013	768.78%
HCI (HCI)	2010-2013	726.48%
Pacira BioSciences (PCRX)	2010-2013	721.29%
Barrett Business Services (BBSI)	2010-2013	709.07%