Freedom (FRHC) had the highest return between 2016 and 2018 by a US stock with a market cap of $5B+, returning 191,993%.

ASSET	YEARS	% RETURN
Freedom (FRHC)	2016-2018	191,993.02%
Madrigal Pharmaceuticals (MDGL)	2016-2018	875.93%
EXACT Sciences (EXAS)	2016-2018	602.67%
Advanced Micro Devices (AMD)	2016-2018	566.43%
Teck Resources Ltd Class B (TECK)	2016-2018	509.76%
Etsy (ETSY)	2016-2018	481.54%
argenx NV ADR (ARGX)	2016-2018	436.7%
Cleveland-Cliffs (CLF)	2016-2018	389.8%
Centrais Electricas Brasileiras (EBR)	2016-2018	384.73%
BeiGene (ONC)	2016-2018	384.16%
Casella Waste Systems (CWST)	2016-2018	382.88%
Vale SA ADR (VALE)	2016-2018	355.08%
TKO (TKO)	2016-2018	352.63%
Block (XYZ)	2016-2018	339.92%
Texas Pacific Land Trust (TPL)	2016-2018	336.05%
NVIDIA (NVDA)	2016-2018	320.24%
Appfolio (APPF)	2016-2018	307.85%
Wix (WIX)	2016-2018	306.39%
Trade Desk (TTD)	2016-2018	303.69%
Ollie's Bargain Outlet Hldg (OLLI)	2016-2018	297.55%
Planet Fitness (PLNT)	2016-2018	290.95%
Burlington Stores (BURL)	2016-2018	288.79%
Huazhu (HTHT)	2016-2018	282.16%
Compania de Minas Buenaventura SAA ADR (BVN)	2016-2018	279.54%
Twilio (TWLO)	2016-2018	272.24%