NVIDIA (NVDA) had the highest return between 1999 and 2001 by a mega-cap US stock, returning 1,174.8%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	1999-2001	1,174.75%
Lam Research (LRCX)	1999-2001	284.36%
UnitedHealth (UNH)	1999-2001	224.05%
Gilead Sciences (GILD)	1999-2001	220.56%
Analog Devices (ADI)	1999-2001	185.24%
Taiwan Semiconductor Manufacturing (TSM)	1999-2001	161.01%
Amgen (AMGN)	1999-2001	115.78%
Citigroup (C)	1999-2001	108.48%
Oracle (ORCL)	1999-2001	89.94%
Applied Materials (AMAT)	1999-2001	87.06%
Toronto Dominion Bank (TD)	1999-2001	64.29%
Morgan Stanley (MS)	1999-2001	63.78%
LIN TV (LIN)	1999-2001	62.48%
Thermo Fisher Scientific (TMO)	1999-2001	61.37%
BHP (BHP)	1999-2001	59.61%
ASML Holding NV New York Registry Shares (ASML)	1999-2001	57.99%
Johnson & Johnson (JNJ)	1999-2001	48.15%
Walmart (WMT)	1999-2001	43.06%
TotalEnergies SE ADR (TTE)	1999-2001	42.13%
Royal Bank of Canada (RY)	1999-2001	41.72%
International Business Machines (IBM)	1999-2001	32.65%
Texas Instruments (TXN)	1999-2001	31.01%
Home Depot (HD)	1999-2001	27.97%
Micron Technology (MU)	1999-2001	24.94%
Goldman Sachs (GS)	1999-2001	23.81%

Mega-cap stocks are treated as having a market cap of $200B+.