Cisco Systems (CSCO) had the highest return between 1992 and 2001 by a mega-cap US stock, returning 3,881.4%.

ASSET	YEARS	% RETURN
Cisco Systems (CSCO)	1992-2001	3,881.36%
Oracle (ORCL)	1992-2001	3,757.59%
Microsoft (MSFT)	1992-2001	1,335.69%
NVIDIA (NVDA)	1992-2001	1,174.56%
ASML Holding NV ADR (ASML)	1992-2001	809.32%
Berkshire Hathaway (BRK.A)	1992-2001	744.69%
Morgan Stanley (MS)	1992-2001	740.68%
GE Aerospace (GE)	1992-2001	681.59%
UnitedHealth (UNH)	1992-2001	666.74%
American Express (AXP)	1992-2001	616.81%
Home Depot (HD)	1992-2001	611.29%
JPMorgan Chase (JPM)	1992-2001	601.33%
International Business Machines (IBM)	1992-2001	536.81%
Wells Fargo (WFC)	1992-2001	517.28%
Raytheon Technologies (RTX)	1992-2001	499.21%
AstraZeneca PLC ADR (AZN)	1992-2001	487.49%
Johnson & Johnson (JNJ)	1992-2001	396.21%
Eli Lilly and (LLY)	1992-2001	379.78%
Caterpillar (CAT)	1992-2001	377.1%
Novo Nordisk A-S (NVO)	1992-2001	376.83%
Bank of America (BAC)	1992-2001	347.89%
Amazon (AMZN)	1992-2001	343.81%
Walmart (WMT)	1992-2001	317.26%
Procter & Gamble (PG)	1992-2001	311.35%
Abbott Laboratories (ABT)	1992-2001	306.8%

Mega-cap stocks are treated as having a market cap of $200B+.