Cisco Systems (CSCO) had the highest return between 1992 and 2001 by a mega-cap US stock, returning 3,880.6%.

ASSET	YEARS	% RETURN
Cisco Systems (CSCO)	1992-2001	3,880.57%
Oracle (ORCL)	1992-2001	3,757.62%
Applied Materials (AMAT)	1992-2001	3,593.11%
Micron Technology (MU)	1992-2001	2,129.26%
Citigroup (C)	1992-2001	1,692.68%
Microsoft (MSFT)	1992-2001	1,335.65%
NVIDIA (NVDA)	1992-2001	1,174.56%
ASML Holding NV ADR (ASML)	1992-2001	809.34%
Lam Research (LRCX)	1992-2001	761.88%
Berkshire Hathaway (BRK.A)	1992-2001	744.69%
Morgan Stanley (MS)	1992-2001	740.67%
GE Aerospace (GE)	1992-2001	681.58%
UnitedHealth (UNH)	1992-2001	666.72%
American Express (AXP)	1992-2001	621.08%
Home Depot (HD)	1992-2001	611.29%
JPMorgan Chase (JPM)	1992-2001	601.33%
International Business Machines (IBM)	1992-2001	536.81%
Wells Fargo (WFC)	1992-2001	517.27%
Raytheon Technologies (RTX)	1992-2001	507.37%
AstraZeneca PLC ADR (AZN)	1992-2001	487.49%
Johnson & Johnson (JNJ)	1992-2001	396.21%
Eli Lilly and (LLY)	1992-2001	379.76%
Novo Nordisk A-S (NVO)	1992-2001	376.83%
Caterpillar (CAT)	1992-2001	376.38%
Bank of America (BAC)	1992-2001	347.9%

Mega-cap stocks are treated as having a market cap of $200B+.