Oracle (ORCL) had the highest return between 1993 and 2002 by a mega-cap US stock, returning 1,448.4%.

ASSET	YEARS	% RETURN
Oracle (ORCL)	1993-2002	1,448.35%
Cisco Systems (CSCO)	1993-2002	1,097.61%
Microsoft (MSFT)	1993-2002	873.17%
Amazon (AMZN)	1993-2002	674.82%
International Business Machines (IBM)	1993-2002	567.31%
Raytheon Technologies (RTX)	1993-2002	521.47%
Berkshire Hathaway (BRK.A)	1993-2002	520.47%
Morgan Stanley (MS)	1993-2002	512.07%
UnitedHealth (UNH)	1993-2002	497.1%
American Express (AXP)	1993-2002	466.72%
Wells Fargo (WFC)	1993-2002	452.75%
Eli Lilly and (LLY)	1993-2002	425.86%
Micron Technology (MU)	1993-2002	419.32%
Johnson & Johnson (JNJ)	1993-2002	402.57%
AstraZeneca PLC ADR (AZN)	1993-2002	350.12%
ASML Holding NV ADR (ASML)	1993-2002	345.86%
GE Aerospace (GE)	1993-2002	317.79%
LIN TV (LIN)	1993-2002	295.09%
Royal Bank of Canada (RY)	1993-2002	294.55%
Bank of America (BAC)	1993-2002	288.55%
Procter & Gamble (PG)	1993-2002	287.35%
Novo Nordisk A-S (NVO)	1993-2002	254.67%
Caterpillar (CAT)	1993-2002	239.47%
Walmart (WMT)	1993-2002	234.64%
Merck (MRK)	1993-2002	222.76%

Mega-cap stocks are treated as having a market cap of $200B+.