NVIDIA (NVDA) had the highest return between 1997 and 2001 by a mega-cap US stock, returning 1,174.6%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	1997-2001	1,174.56%
Shell PLC ADR (SHEL)	1997-2001	434.69%
Walmart (WMT)	1997-2001	414.36%
Home Depot (HD)	1997-2001	364.47%
Amazon (AMZN)	1997-2001	343.81%
ASML Holding NV ADR (ASML)	1997-2001	313.33%
Morgan Stanley (MS)	1997-2001	259.9%
Costco Wholesale (COST)	1997-2001	251.52%
International Business Machines (IBM)	1997-2001	224.26%
Microsoft (MSFT)	1997-2001	218.8%
UnitedHealth (UNH)	1997-2001	215.39%
Oracle (ORCL)	1997-2001	195.06%
SAP SE ADR (SAP)	1997-2001	181.28%
GE Aerospace (GE)	1997-2001	161.3%
Cisco Systems (CSCO)	1997-2001	156.18%
Johnson & Johnson (JNJ)	1997-2001	153.11%
Abbott Laboratories (ABT)	1997-2001	137.97%
Novo Nordisk A-S (NVO)	1997-2001	130.57%
Eli Lilly and (LLY)	1997-2001	129.48%
Berkshire Hathaway (BRK.B)	1997-2001	127.48%
Berkshire Hathaway (BRK.A)	1997-2001	123.01%
Taiwan Semiconductor Manufacturing (TSM)	1997-2001	121.16%
Wells Fargo (WFC)	1997-2001	120.3%
Raytheon Technologies (RTX)	1997-2001	109.02%
Apple (AAPL)	1997-2001	107.38%

Mega-cap stocks are treated as having a market cap of $200B+.