Tesla (TSLA) had the highest return between 2017 and 2021 by a mega-cap US stock, returning 2,359.2%.

ASSET	YEARS	% RETURN
Tesla (TSLA)	2017-2021	2,359.23%
Advanced Micro Devices (AMD)	2017-2021	1,160.07%
NVIDIA (NVDA)	2017-2021	1,041.74%
ASML Holding NV ADR (ASML)	2017-2021	653.45%
Lam Research (LRCX)	2017-2021	630.55%
Marvell Technology (MRVL)	2017-2021	558.08%
Apple (AAPL)	2017-2021	551.63%
KLA (KLAC)	2017-2021	504.94%
Arista Networks (ANET)	2017-2021	489.5%
Microsoft (MSFT)	2017-2021	476.08%
Applied Materials (AMAT)	2017-2021	418.28%
Netflix (NFLX)	2017-2021	382.11%
Taiwan Semiconductor Manufacturing (TSM)	2017-2021	377.47%
Thermo Fisher Scientific (TMO)	2017-2021	374.92%
Palo Alto Networks (PANW)	2017-2021	342.4%
Amazon (AMZN)	2017-2021	339.93%
Broadcom (AVGO)	2017-2021	339.25%
Micron Technology (MU)	2017-2021	323.11%
Eli Lilly and (LLY)	2017-2021	316.07%
Costco Wholesale (COST)	2017-2021	295.85%
Seagate Technology (STX)	2017-2021	276.47%
Dell Technologies (DELL)	2017-2021	263.63%
Alphabet Inc Class A (GOOGL)	2017-2021	261.85%
Mastercard (MA)	2017-2021	254.14%
Home Depot (HD)	2017-2021	244.98%

Mega-cap stocks are treated as having a market cap of $200B+.