Regencell Bioscience (RGC) had the highest return between 2024 and 2025 by a mid-cap US stock, returning 7,500.4%.

ASSET	YEARS	% RETURN
Regencell Bioscience (RGC)	2024-2025	7,500.43%
GeneDx (WGS)	2024-2025	4,717.04%
D-Wave Quantum Inc Common Stock (QBTS)	2024-2025	2,871.59%
Dave (DAVE)	2024-2025	2,616.69%
Rigetti Computing (RGTI)	2024-2025	2,115%
Sezzle (SEZL)	2024-2025	1,713.57%
Praxis Precision Medicines (PRAX)	2024-2025	1,225.27%
Abivax SA American Depositary Shares (ABVX)	2024-2025	1,186.78%
Almonty Industries Inc Common Shares (ALM)	2024-2025	859.69%
Kodiak Sciences (KOD)	2024-2025	835.12%
Trevi Therapeutics (TRVI)	2024-2025	820.59%
Arcutis Biotherapeutics (ARQT)	2024-2025	816.09%
Planet Labs PBC (PL)	2024-2025	701.63%
Perpetua Resources (PPTA)	2024-2025	651.86%
Aura Minerals Inc Common Shares (AUGO)	2024-2025	651.52%
Tutor Perini (TPC)	2024-2025	644.49%
Palvella Therapeutics (PVLA)	2024-2025	599.67%
Celcuity LLC (CELC)	2024-2025	588.81%
Argan (AGX)	2024-2025	588.69%
AXT (AXTI)	2024-2025	581.25%
Oklo (OKLO)	2024-2025	577.62%
Innodata (INOD)	2024-2025	536.88%
Ondas (ONDS)	2024-2025	521.66%
Intuitive Machines (LUNR)	2024-2025	517.11%
GRAIL, LLC (GRAL)	2024-2025	513.55%

Mid-cap stocks are treated as having a market cap between $2B and $10B.