QXO (QXO) had the highest return between 2011 and 2015 by a US stock with a market cap of $2B+, returning 3,068,850%.

ASSET	YEARS	% RETURN
QXO (QXO)	2011-2015	3,068,850%
Inventrust Properties (IVT)	2011-2015	751,855%
ACADIA Pharmaceuticals (ACAD)	2011-2015	2,895.8%
Vipshop (VIPS)	2011-2015	2,444.97%
Patrick Industries (PATK)	2011-2015	2,064.2%
Cidara Therapeutics (CDTX)	2011-2015	2,045%
Travere Therapeutics (TVTX)	2011-2015	2,043.33%
Regeneron Pharmaceuticals (REGN)	2011-2015	1,560.66%
Expedia (EXPE)	2011-2015	1,171.02%
Ligand Pharmaceuticals (LGND)	2011-2015	1,108.69%
CleanSpark (CLSK)	2011-2015	1,053.86%
Nexstar Broadcasting (NXST)	2011-2015	924.9%
Genmab A-S (GMAB)	2011-2015	892.74%
Alnylam Pharmaceuticals (ALNY)	2011-2015	849.95%
Acadia Healthcare (ACHC)	2011-2015	818.53%
Tesla (TSLA)	2011-2015	794.19%
Manhattan Associates (MANH)	2011-2015	760.47%
Tyler Technologies (TYL)	2011-2015	732.47%
Ambarella (AMBA)	2011-2015	730.7%
Silicon Motion Technology (SIMO)	2011-2015	700.28%
Lithia Motors (LAD)	2011-2015	675.61%
Domino's Pizza Inc Common Stock (DPZ)	2011-2015	675.19%
Neurocrine Biosciences (NBIX)	2011-2015	632.77%
Jazz Pharmaceuticals (JAZZ)	2011-2015	607.04%
Cheniere Energy (LNG)	2011-2015	562.81%