Weatherford International (WFRD) had the highest return between 2016 and 2019 by a US stock with a market cap of $2B+, returning 480,991.2%.

ASSET	YEARS	% RETURN
Weatherford International (WFRD)	2016-2019	480,991.23%
Freedom (FRHC)	2016-2019	338,039.53%
Advanced Micro Devices (AMD)	2016-2019	1,555.6%
Quantum Computing (QUBT)	2016-2019	1,400%
Axsome Therapeutics (AXSM)	2016-2019	983.44%
Arrowhead Pharmaceuticals (ARWR)	2016-2019	962.48%
EXACT Sciences (EXAS)	2016-2019	929.84%
Skyline (SKY)	2016-2019	866.08%
Trade Desk (TTD)	2016-2019	803.58%
argenx NV ADR (ARGX)	2016-2019	796.76%
Roku (ROKU)	2016-2019	748.54%
Madrigal Pharmaceuticals (MDGL)	2016-2019	688.83%
Casella Waste Systems (CWST)	2016-2019	680.17%
Ascendis Pharma A-S (ASND)	2016-2019	670.32%
Enphase Energy (ENPH)	2016-2019	661.81%
Appfolio (APPF)	2016-2019	657.23%
NVIDIA (NVDA)	2016-2019	643.57%
Centrais Electricas Brasileiras (EBR)	2016-2019	632.82%
Ringcentral (RNG)	2016-2019	629.86%
Paycom Soft (PAYC)	2016-2019	613.45%
Freshpet (FRPT)	2016-2019	609.36%
Leonardo DRS, Inc Common Stock (DRS)	2016-2019	582.88%
Carvana (CVNA)	2016-2019	581.85%
Novanta (NOVT)	2016-2019	560.49%
Match (MTCH)	2016-2019	542.38%