Rigetti Computing (RGTI) has had the highest return between 2024 and 2025 by a US stock in the Nasdaq Composite (IXIC) with a market cap of $10B+, returning 4,538%.

ASSET	YEARS	% RETURN
Rigetti Computing (RGTI)	2024-2025	4,538%
Applovin (APP)	2024-2025	1,420.71%
Ast Spacemobile (ASTS)	2024-2025	1,324.74%
Rocket Lab USA (RKLB)	2024-2025	1,115.96%
Palantir Technologies Inc Class A Common Stock (PLTR)	2024-2025	951.03%
Robinhood Markets (HOOD)	2024-2025	919.7%
Summit Therapeutics (SMMT)	2024-2025	713.57%
IREN (IREN)	2024-2025	672.52%
Credo Technology (CRDO)	2024-2025	654.65%
Nebius (NBIS)	2024-2025	498.94%
Insmed (INSM)	2024-2025	438.18%
Flex (FLEX)	2024-2025	356.52%
EchoStar (SATS)	2024-2025	347.9%
Astera Labs, Inc Common Stock (ALAB)	2024-2025	343.89%
MicroStrategy (MSTR)	2024-2025	318.59%
Kratos Defense & Security Solutions (KTOS)	2024-2025	309.66%
Sterling Construction (STRL)	2024-2025	308.71%
NVIDIA (NVDA)	2024-2025	272.23%
Fortress Transp & Infra Inv (FTAI)	2024-2025	267.55%
CoreWeave, Inc Class A Common Stock (CRWV)	2024-2025	242.18%
Constellation Energy (CEG)	2024-2025	235.83%
Mr Cooper (COOP)	2024-2025	228.74%
Broadcom (AVGO)	2024-2025	226.48%
Western Digital (WDC)	2024-2025	223.55%
Interactive Brokers (IBKR)	2024-2025	221.91%