Monster Beverage (MNST) had the highest return between 2004 and 2020 by a US stock in the S&P 500 (GSPC), returning 52,625.2%.

ASSET	YEARS	% RETURN
Monster Beverage (MNST)	2004-2020	52,625.2%
Apple (AAPL)	2004-2020	39,879.16%
Tesla (TSLA)	2004-2020	18,469.76%
Intuitive Surgical (ISRG)	2004-2020	14,252.63%
Netflix (NFLX)	2004-2020	13,065.74%
Booking (BKNG)	2004-2020	12,239.46%
Mastercard (MA)	2004-2020	9,374.52%
Texas Pacific Land Trust (TPL)	2004-2020	8,241.69%
NVIDIA (NVDA)	2004-2020	7,133.22%
Amazon (AMZN)	2004-2020	6,073.1%
Salesforce (CRM)	2004-2020	5,834.17%
Transdigm (TDG)	2004-2020	5,812.42%
Domino's Pizza Inc Common Stock (DPZ)	2004-2020	5,657.8%
MarketAxess (MKTX)	2004-2020	5,149.43%
Monolithic Power Systems (MPWR)	2004-2020	4,453.6%
Tyler Technologies (TYL)	2004-2020	4,386.33%
Old Dominion Freight Line (ODFL)	2004-2020	4,340.68%
IDEXX Laboratories (IDXX)	2004-2020	4,194.42%
West Pharmaceutical Services (WST)	2004-2020	3,962.48%
Deckers Outdoor (DECK)	2004-2020	3,939.27%
Edwards Lifesciences (EW)	2004-2020	3,538.29%
Alphabet Inc Class A (GOOGL)	2004-2020	3,401.61%
Broadcom (AVGO)	2004-2020	3,241.94%
Regeneron Pharmaceuticals (REGN)	2004-2020	3,162.05%
Align Technology (ALGN)	2004-2020	3,092.23%