Expedia (EXPE) had the highest return between 2011 and 2016 by a US stock in the S&P 500 (GSPC), returning 1,068.7%.

ASSET	YEARS	% RETURN
Expedia (EXPE)	2011-2016	1,068.72%
Regeneron Pharmaceuticals (REGN)	2011-2016	1,022.94%
Domino's Pizza Inc Common Stock (DPZ)	2011-2016	1,021.59%
Texas Pacific Land Trust (TPL)	2011-2016	749.97%
Tesla (TSLA)	2011-2016	696.13%
Ulta Beauty (ULTA)	2011-2016	655.33%
NVIDIA (NVDA)	2011-2016	639.11%
Charter Communications (CHTR)	2011-2016	636.75%
Constellation Brands Inc Class A (STZ)	2011-2016	603.12%
Tyler Technologies (TYL)	2011-2016	581.81%
Broadcom (AVGO)	2011-2016	576.83%
Incyte (INCY)	2011-2016	505.5%
Diamondback Energy (FANG)	2011-2016	467.12%
Builders FirstSource (BLDR)	2011-2016	448.5%
Transdigm (TDG)	2011-2016	446.68%
Huntington Ingalls Industries (HII)	2011-2016	440.57%
Monolithic Power Systems (MPWR)	2011-2016	435.74%
Smith AO (AOS)	2011-2016	432%
Fair Isaac (FICO)	2011-2016	410.33%
Axon Enterprise (AXON)	2011-2016	410.32%
Monster Beverage (MNST)	2011-2016	405.3%
Pool (POOL)	2011-2016	403.11%
Netflix (NFLX)	2011-2016	395.2%
Align Technology (ALGN)	2011-2016	386.73%
UnitedHealth (UNH)	2011-2016	382.87%