Twenty One Capital (XXI) had the highest return in April 2025 by a small-cap US stock, returning 302%.

ASSET	MONTH	% RETURN
Twenty One Capital (XXI)	April 2025	302%
Oncology Institute (STLN)	April 2025	101.63%
Agenus (AGEN)	April 2025	91.39%
ThredUp (TDUP)	April 2025	87.08%
Rezolve AI Limited Ordinary Shares (RZLV)	April 2025	83.33%
Hertz Global (HTZ)	April 2025	76.23%
Nutex Health (NUTX)	April 2025	69.18%
InflaRx (IFRX)	April 2025	68.32%
American Battery Technology Company Common Stock (ABAT)	April 2025	66.02%
Forward Industries (FWDI)	April 2025	65.04%
Reading International B (RDIB)	April 2025	63.11%
Lexicon Pharmaceuticals (LXRX)	April 2025	58.49%
Goldgroup Mining (GORO)	April 2025	56.25%
Roma Green Finance Limited Ordinary Shares (ROMA)	April 2025	55.41%
CorMedix (CRMD)	April 2025	51.15%
Canopy Growth (CGC)	April 2025	48.39%
Stoke Therapeutics (STOK)	April 2025	48.1%
Yalla Group (YALA)	April 2025	46.93%
MMTEC (MTC)	April 2025	46.34%
XMax (XMAX)	April 2025	45.71%
United States Antimony (UAMY)	April 2025	45.25%
Compass Minerals International (CMP)	April 2025	44.67%
Upstream Bio (UPB)	April 2025	43.79%
Editas Medicine (EDIT)	April 2025	43.48%
Coincheck Group NV Ordinary Shares (CNCK)	April 2025	42.19%

Small-cap stocks are treated as having a market cap between $300M and $2B.