Capricor Therapeutics (CAPR) had the highest return in December 2025 by a small-cap US stock, returning 439.4%.

ASSET	MONTH	% RETURN
Capricor Therapeutics (CAPR)	December 2025	439.44%
Sellas Life Sciences (SLS)	December 2025	138.61%
Wave Life Sciences (WVE)	December 2025	123.68%
Climb Bio (CLYM)	December 2025	113.9%
Sable Offshore (SOC)	December 2025	113.24%
CapsoVision, Inc Common Stock (CV)	December 2025	105.18%
Innovative Aerosystems (IA)	December 2025	97.7%
Structure Therapeutics Inc American Depositary Shares (GPCR)	December 2025	97.25%
Hycroft Mining (HYMC)	December 2025	91.93%
Frequency Electronics (FEIM)	December 2025	91.26%
Designer Brands (DBI)	December 2025	78.38%
Intuitive Machines (LUNR)	December 2025	76.22%
Omeros (OMER)	December 2025	74.72%
Prelude Therapeutics (PRLD)	December 2025	73.65%
T1 Energy (TE)	December 2025	65.76%
Shattuck Labs (STTK)	December 2025	62.22%
Andersen (ANDG)	December 2025	62.06%
Agencia Comercial Spirits Ltd Class A Ordinary Shares (AGCC)	December 2025	58.7%
Vor Biopharma (VOR)	December 2025	57.02%
Gray Television (GTN.A)	December 2025	56.05%
LightPath Technologies (LPTH)	December 2025	51.26%
Cementos Pacasmayo SAA ADR (CPAC)	December 2025	50.58%
Unusual Machines (UMAC)	December 2025	48.31%
Dingdong (Cayman) Limited ADR (DDL)	December 2025	44.77%
DBV Technologies (DBVT)	December 2025	43.6%

Small-cap stocks are treated as having a market cap between $300M and $2B.