Eightco (ORBS) had the highest return in September 2025 by a small-cap US stock, returning 518.2%.

ASSET	MONTH	% RETURN
Eightco (ORBS)	September 2025	518.24%
New Era Energy & Digital (NUAI)	September 2025	309.8%
Bakkt (BKKT)	September 2025	295.42%
XMax (XMAX)	September 2025	214.86%
Etoiles Capital Group Co, Ltd Class A Ordinary Shares (EFTY)	September 2025	156.5%
Stewards Inc Common Stock (SWRD)	September 2025	152%
Monopar Therapeutics (MNPR)	September 2025	149.22%
Shattuck Labs (STTK)	September 2025	141.41%
Nanobiotix (NBTX)	September 2025	127.86%
BTQ Technologies Corp Common Stock (BTQ)	September 2025	122.51%
Zura Bio Limited - Class A Ordinary shares (ZURA)	September 2025	115.42%
Clearpoint Neuro (CLPT)	September 2025	111.76%
BitVentures (BVC)	September 2025	103.65%
American Battery Technology Company Common Stock (ABAT)	September 2025	100.83%
Lithium Americas (LAC)	September 2025	95.55%
FuelCell Energy (FCEL)	September 2025	90.24%
Olema Pharmaceuticals (OLMA)	September 2025	78.65%
Relmada Therapeutics (RLMD)	September 2025	77.88%
Maze Therapeutics, Inc Common Stock (MAZE)	September 2025	77.12%
Prime Medicine, Inc Common Stock (PRME)	September 2025	74.76%
Eos Energy Enterprises (EOSE)	September 2025	69.75%
Forward Industries (FWDI)	September 2025	69.23%
Prenetics Global (PRE)	September 2025	68.35%
Rapport Therapeutics, Inc Common Stock (RAPP)	September 2025	67.8%
Vista Gold (VGZ)	September 2025	66.41%

Small-cap stocks are treated as having a market cap between $300M and $2B.