best performing stock in the last 3 years with a market cap of 3 billion +

Soleno Therapeutics (SLNO) has had the highest return between October 10, 2022 and October 10, 2025 by a US stock with a market cap of $3B+, returning 4,168.2%.

ASSET DATE % RETURN
Soleno Therapeutics (SLNO)
10/10/2022 - 10/10/2025
4,168.23%
QMMM Holdings Limited Ordinary Shares (QMMM)
10/10/2022 - 10/10/2025
3,880%
Applovin (APP)
10/10/2022 - 10/10/2025
2,991.25%
Celestica (CLS)
10/10/2022 - 10/10/2025
2,770.5%
Rigetti Computing (RGTI)
10/10/2022 - 10/10/2025
2,392.59%
Regencell Bioscience (RGC)
10/10/2022 - 10/10/2025
2,202.98%
Palantir Technologies Inc Class A Common Stock (PLTR)
10/10/2022 - 10/10/2025
2,170.13%
Summit Therapeutics (SMMT)
10/10/2022 - 10/10/2025
2,057.14%
Carvana (CVNA)
10/10/2022 - 10/10/2025
1,770.29%
Applied Digital (APLD)
10/10/2022 - 10/10/2025
1,742.14%
IREN (IREN)
10/10/2022 - 10/10/2025
1,625.68%
NVIDIA (NVDA)
10/10/2022 - 10/10/2025
1,501.61%
Cipher Mining (CIFR)
10/10/2022 - 10/10/2025
1,492.04%
Sterling Construction (STRL)
10/10/2022 - 10/10/2025
1,478.73%
Vertiv (VRT)
10/10/2022 - 10/10/2025
1,439.36%
Rocket Lab USA (RKLB)
10/10/2022 - 10/10/2025
1,423.39%
Powell Industries (POWL)
10/10/2022 - 10/10/2025
1,415.1%
MicroStrategy (MSTR)
10/10/2022 - 10/10/2025
1,358.38%
IONQ (IONQ)
10/10/2022 - 10/10/2025
1,356.77%
Oklo (OKLO)
10/10/2022 - 10/10/2025
1,315.27%
Robinhood Markets (HOOD)
10/10/2022 - 10/10/2025
1,309.32%
IES (IESC)
10/10/2022 - 10/10/2025
1,298.87%
Credo Technology (CRDO)
10/10/2022 - 10/10/2025
1,285.43%
Viking Therapeutics (VKTX)
10/10/2022 - 10/10/2025
1,114.58%
Ast Spacemobile (ASTS)
10/10/2022 - 10/10/2025
1,097.1%