best performing stock in the last 4 years with a market cap of 4 billion +

QMMM Holdings Limited Ordinary Shares (QMMM) has had the highest return between October 10, 2021 and October 10, 2025 by a US stock with a market cap of $4B+, returning 3,880%.

ASSET DATE % RETURN
QMMM Holdings Limited Ordinary Shares (QMMM)
10/10/2021 - 10/10/2025
3,880%
Regencell Bioscience (RGC)
10/10/2021 - 10/10/2025
3,564.55%
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10/10/2021 - 10/10/2025
2,702.37%
Verona Pharma PLC ADR (VRNA)
10/10/2021 - 10/10/2025
2,270.51%
Super Micro Computer (SMCI)
10/10/2021 - 10/10/2025
1,470%
Sterling Construction (STRL)
10/10/2021 - 10/10/2025
1,416.77%
Oklo (OKLO)
10/10/2021 - 10/10/2025
1,316.72%
Vistra Energy (VST)
10/10/2021 - 10/10/2025
1,170.88%
Modine Manufacturing (MOD)
10/10/2021 - 10/10/2025
1,166.44%
Credo Technology (CRDO)
10/10/2021 - 10/10/2025
1,149.17%
Applied Digital (APLD)
10/10/2021 - 10/10/2025
1,120.31%
Comfort Systems USA (FIX)
10/10/2021 - 10/10/2025
983.53%
Constellation Energy (CEG)
10/10/2021 - 10/10/2025
941.78%
Centrus Energy (LEU)
10/10/2021 - 10/10/2025
861.12%
NVIDIA (NVDA)
10/10/2021 - 10/10/2025
837.75%
Fortress Transp & Infra Inv (FTAI)
10/10/2021 - 10/10/2025
797.23%
IONQ (IONQ)
10/10/2021 - 10/10/2025
783.69%
Rhythm Pharmaceuticals (RYTM)
10/10/2021 - 10/10/2025
772.91%
Ast Spacemobile (ASTS)
10/10/2021 - 10/10/2025
767.9%
IES (IESC)
10/10/2021 - 10/10/2025
755.59%
Palantir Technologies Inc Class A Common Stock (PLTR)
10/10/2021 - 10/10/2025
697.38%
Carpenter Technology (CRS)
10/10/2021 - 10/10/2025
685.36%
Abivax SA American Depositary Shares (ABVX)
10/10/2021 - 10/10/2025
681.12%
Broadcom (AVGO)
10/10/2021 - 10/10/2025
661.55%
Vertiv (VRT)
10/10/2021 - 10/10/2025
659.63%