Hirequest (HQI) had the highest return between 1999 and 2006 by a US stock, returning 27,792,300%.

ASSET	YEARS	% RETURN
Hirequest (HQI)	1999-2006	27,792,300%
InterContinental Hotels Group PLC ADR (IHG)	1999-2006	16,461,200%
India Globalization Capital (IGC)	1999-2006	9,733,233.33%
Know Labs (KNW)	1999-2006	7,785,769.97%
Houston American Energy (HUSA)	1999-2006	1,839,593.97%
Perspective Therapeutics (CATX)	1999-2006	1,633,233.33%
National Grid PLC ADR (NGG)	1999-2006	1,344,788.24%
Taoping (TAOP)	1999-2006	1,319,988.01%
Cemtrex (CETX)	1999-2006	1,293,451.36%
Enveric Biosciences (ENVB)	1999-2006	1,120,927.56%
Alto Ingredients (ALTO)	1999-2006	1,108,233.33%
Ocean Power Technologies (OPTT)	1999-2006	188,788.89%
Inseego (INSG)	1999-2006	161,066.67%
Flexible Solutions International (FSI)	1999-2006	57,313.73%
ImmunoPrecise Antibodies (HYFT)	1999-2006	35,900%
Theriva Biologics (TOVX)	1999-2006	26,008.13%
Insmed (INSM)	1999-2006	20,753.08%
Gyre Therapeutics (GYRE)	1999-2006	19,089.16%
First Majestic Silver (AG)	1999-2006	18,233.33%
NanoViricides (NNVC)	1999-2006	10,260%
TherapeuticsMD (TXMD)	1999-2006	9,900.01%
Oramed Pharmaceuticals (ORMP)	1999-2006	6,866.14%
QVC (QVCGA)	1999-2006	6,259.17%
Companhia Siderurgica Nacional ADR (SID)	1999-2006	5,648.91%
Monster Beverage (MNST)	1999-2006	4,920.93%