BioNTech SE (BNTX) had the highest return in April 2021 by a US stock with a market cap of $20B+, returning 70.4%.

ASSET	MONTH	% RETURN
BioNTech SE (BNTX)	April 2021	70.37%
Equifax (EFX)	April 2021	26.46%
IQVIA (IQV)	April 2021	20.34%
Seagate Technology (STX)	April 2021	20.17%
United Parcel Service (UPS)	April 2021	19.79%
Imperial Oil (IMO)	April 2021	19.63%
Blackstone (BX)	April 2021	18.62%
Nokia (NOK)	April 2021	17%
Centrais Electricas Brasileiras (EBR)	April 2021	16.78%
Capital One Financial (COF)	April 2021	16.1%
Brown & Brown (BRO)	April 2021	16.09%
Deutsche Bank (DB)	April 2021	16.09%
Arthur J Gallagher (AJG)	April 2021	16.04%
Apollo Global Management LLC Class A (APO)	April 2021	16.01%
Cloudflare (NET)	April 2021	15.81%
Vale SA ADR (VALE)	April 2021	15.7%
Wells Fargo (WFC)	April 2021	15.63%
Intuitive Surgical (ISRG)	April 2021	15.33%
Carlyle (CG)	April 2021	15.14%
Tapestry (TPR)	April 2021	14.94%
Centrais Elétricas Brasileiras SA - Eletrobrás (EBR.B)	April 2021	14.78%
MSCI (MSCI)	April 2021	14.67%
KKR (KKR)	April 2021	14.19%
PPG Industries (PPG)	April 2021	13.96%
Edwards Lifesciences (EW)	April 2021	13.74%