Know Labs (KNW) had the highest return between 2001 and 2010 by a US stock, returning 4,885,152.2%.

ASSET	YEARS	% RETURN
Know Labs (KNW)	2001-2010	4,885,152.16%
Perspective Therapeutics (CATX)	2001-2010	376,566.67%
Aris Mining (ARMN)	2001-2010	326,443.75%
Gulf Resources (GURE)	2001-2010	53,350%
Ferguson (FERG)	2001-2010	45,623.49%
Houston American Energy (HUSA)	2001-2010	37,506.02%
Pioneer Power Solutions (PPSI)	2001-2010	29,429.23%
Future Fintech (FTFT)	2001-2010	23,150%
Frontline (FRO)	2001-2010	18,505.98%
Companhia Siderurgica Nacional ADR (SID)	2001-2010	16,200.97%
MEDIFAST (MED)	2001-2010	15,102.99%
Ainos (AIMD)	2001-2010	11,328.57%
Monster Beverage (MNST)	2001-2010	10,874.06%
Ziff Davis (ZD)	2001-2010	10,192.59%
DXP Enterprises (DXPE)	2001-2010	8,431.82%
PetMed Express (PETS)	2001-2010	7,279.79%
Encore Capital (ECPG)	2001-2010	6,600%
EZCORP (EZPW)	2001-2010	6,492.95%
Companhia Energetica de Minas Gerais CEMIG Pref ADR (CIG)	2001-2010	6,247.66%
BRF SA ADR (BRFS)	2001-2010	5,952.55%
BTCS (BTCS)	2001-2010	5,920%
China Yuchai International (CYD)	2001-2010	5,046.65%
McEwen Mining (MUX)	2001-2010	4,942.18%
USANA Health Sciences (USNA)	2001-2010	4,866.85%
Booking (BKNG)	2001-2010	4,743.25%